hearing loss

8 papers

Research evidence summary

Q: Does molecular hydrogen help with hearing loss?

A: Of 8 peer-reviewed papers, 7 reported a positive effect (the most common), 1 limited/mixed, 0 negative, 0 not assessed. Study mix: 0 human (0 RCT), 8 animal/basic, 0 meta-analysis or synthesis. The most studied delivery route is inhalation. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	0	of which RCT	0
Animal/basic	8	Synthesis/meta	0
Reported effect	positive 7 ・ limited/mixed 1 ・ negative 0 ・ not assessed 0

Read the safety notes →

Delivery-method distribution

inhalation: 4 hydrogen-rich water: 2 injection / infusion: 1 in vitro: 1

Taurine, Coenzyme Q, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse.
2023 ・ Hear Res ・ PMID 36577362

hydrogen-rich water positive animal study
Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study.
2023 ・ Ann Otol Rhinol Laryngol ・ PMID 35962590

inhalation positive animal study
Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss.
2021 ・ Front Cell Neurosci ・ PMID 34140880

inhalation mixed animal study
Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil.
2018 ・ Neurosci Lett ・ PMID 29223865

injection / infusion positive animal study
Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species.
2014 ・ Neurosci Res ・ PMID 25196919

inhalation positive animal study
Hydrogen protects auditory hair cells from cisplatin-induced free radicals.
2014 ・ Neurosci Lett ・ PMID 25064701

in vitro positive in vitro study
Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils.
2012 ・ Acta Pharmacol Sin ・ PMID 22388074

inhalation positive animal study
Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs.
2011 ・ Neurosci Lett ・ PMID 20888392

hydrogen-rich water positive animal study