intestinal injury

54 papers

Research evidence summary

Q: Does molecular hydrogen help with intestinal injury?

A: Of 54 peer-reviewed papers, 39 reported a positive effect (the most common), 2 limited/mixed, 0 negative, 13 not assessed. Study mix: 2 human (1 RCT), 42 animal/basic, 9 meta-analysis or synthesis. The most studied delivery route is hydrogen-rich water. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	2	of which RCT	1
Animal/basic	42	Synthesis/meta	9
Reported effect	positive 39 ・ limited/mixed 2 ・ negative 0 ・ not assessed 13

Read the safety notes →

Delivery-method distribution

hydrogen-rich water: 22 not specified: 9 inhalation: 8 mixed routes: 5 injection / infusion: 4 in vitro: 3 animal model: 3

Protective effects of hydrogen-rich saline on ulcerative colitis rat model.
2013 ・ J Surg Res ・ PMID 23773716

injection / infusion positive animal study
Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing hydrogen production.
2013 ・ Dig Dis Sci ・ PMID 23371012

mixed routes positive animal study
Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.
2009 ・ Biochem Biophys Res Commun ・ PMID 19486890

hydrogen-rich water positive animal study
Dietary fibre and health: the role of hydrogen production.
1988 ・ Med Hypotheses ・ PMID 2849711

not specified not assessed other