# Quantitative structure-permeation relationships for solute transport across silicone membranes.
> シリコーン膜における溶質透過の定量的構造透過関係


## Abstract

This study examined the molecular determinants of solute permeation across silicone membranes and compared findings with human epidermal transport. Permeability coefficients (log Kp) for a series of model compounds were derived using a pseudosteady-state diffusion model. Structure-permeation relationships were constructed, with particular attention to the difference between octanol/water and 1,2-dichloroethane/water partition coefficients (deltalog P(oct-dce)) as an index of hydrogen-bond donor activity, alongside computationally derived hydrogen-bonding potential. Results indicated that hydrogen-bond donor acidity and lipophilicity were the principal factors governing membrane permeation. For a subset of compounds, a significant correlation was found between silicone membrane permeability and human epidermal flux, suggesting that silicone membranes may serve as a predictive model for biological barrier transport.

### Mechanism

Hydrogen-bond donor acidity and lipophilicity were identified as the primary molecular properties controlling solute permeation across silicone membranes, with a measurable correlation to human epidermal transport observed for selected compounds.

## Bibliographic

- **Authors**: Geinoz S, Rey S, Boss G, Bunge AL, Guy RH, Carrupt PA, et al.
- **Journal**: Pharm Res
- **Year**: 2002
- **PMID**: [12458667](https://pubmed.ncbi.nlm.nih.gov/12458667/)
- **DOI**: [10.1023/a:1020745026766](https://doi.org/10.1023/a:1020745026766)
- **Study type**: in vitro study
- **Delivery route**: in vitro
- **Effect reported**: not assessed

## Delivery context

This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 12458667. https://h2-papers.org/en/papers/12458667
> **Source**: PubMed PMID [12458667](https://pubmed.ncbi.nlm.nih.gov/12458667/)