# Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.
> シスプラチン誘発腎毒性に対する分子状水素の軽減効果と抗腫瘍活性への非干渉性


## Abstract

Cisplatin is an effective anti-cancer agent whose clinical utility is constrained by oxidative stress-mediated kidney damage. In this study, mice received cisplatin followed by either 1% H2 gas inhalation or ad libitum consumption of hydrogen-rich water (0.8 mM). Both delivery approaches reduced oxidative stress markers and improved survival rates and body-weight maintenance. Renal function, assessed via serum creatinine and blood urea nitrogen (BUN), was significantly improved, and histological examination revealed reduced apoptosis in kidney tissue. Critically, hydrogen did not diminish cisplatin's anti-tumor activity against cancer cell lines in vitro or in tumor-bearing mice in vivo, suggesting that H2 selectively mitigates toxic side effects without interfering with the intended pharmacological action of the drug.

### Mechanism

H2 selectively scavenges excess reactive oxygen species generated by cisplatin, thereby suppressing oxidative stress and reducing apoptosis in renal tubular cells without neutralizing the drug's cytotoxic effects on tumor cells.

## Bibliographic

- **Authors**: Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S
- **Journal**: Cancer Chemother Pharmacol
- **Year**: 2009
- **PMID**: [19148645](https://pubmed.ncbi.nlm.nih.gov/19148645/)
- **DOI**: [10.1007/s00280-008-0924-2](https://doi.org/10.1007/s00280-008-0924-2)
- **Study type**: animal study
- **Delivery route**: mixed routes
- **Effect reported**: positive
- **H2 concentration**: 1%

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 19148645. https://h2-papers.org/en/papers/19148645
> **Source**: PubMed PMID [19148645](https://pubmed.ncbi.nlm.nih.gov/19148645/)