# Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study.
> 潜在的メタボリックシンドローム患者における水素水摂取が抗酸化状態に及ぼす影響：オープンラベルパイロット試験


## Abstract

Metabolic syndrome involves cardiometabolic risk factors such as obesity, insulin resistance, hypertension, and dyslipidemia, with oxidative stress playing a central role in its pathogenesis. This 8-week open-label pilot study enrolled 20 subjects with potential metabolic syndrome who consumed 1.5–2 L per day of hydrogen-rich water generated by a magnesium stick (hydrogen concentration: 0.55–0.65 mM). After 8 weeks, superoxide dismutase (SOD) activity increased by 39% (p<0.05) and urinary thiobarbituric acid reactive substances (TBARS) decreased by 43% (p<0.05). HDL-cholesterol rose by 8% and the total cholesterol/HDL ratio declined by 13% from baseline to week 4. Fasting glucose levels remained unchanged throughout the study period. These findings suggest that hydrogen-rich water consumption may favorably modulate antioxidant and lipid parameters in individuals at risk for metabolic syndrome.

### Mechanism

Molecular hydrogen in hydrogen-rich water is thought to scavenge reactive oxygen species, upregulate superoxide dismutase (SOD) activity, and reduce lipid peroxidation products (TBARS), thereby alleviating oxidative stress associated with metabolic syndrome.

## Bibliographic

- **Authors**: Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N
- **Journal**: J Clin Biochem Nutr
- **Year**: 2010
- **PMID**: [20216947](https://pubmed.ncbi.nlm.nih.gov/20216947/)
- **DOI**: [10.3164/jcbn.09-100](https://doi.org/10.3164/jcbn.09-100)
- **PMC**: [PMC2831093](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831093/)
- **Study type**: human observational study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 20216947. https://h2-papers.org/en/papers/20216947
> **Source**: PubMed PMID [20216947](https://pubmed.ncbi.nlm.nih.gov/20216947/)