# Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.
> 宇宙飛行における放射線誘発性酸化ストレスリスクに対する水素の潜在的効果に関する仮説


## Abstract

Cosmic radiation poses significant health risks to astronauts by inducing DNA and lipid damage through elevated oxidative stress. Molecular hydrogen, recognized for its potent antioxidant and anti-inflammatory properties, is proposed here as a potential preventive agent against radiation-induced adverse events in space. The authors hypothesize that administering H2 via inhalation or hydrogen-rich water consumption could offer a practical and feasible approach to mitigating these risks. Given the anticipated growth in space mission frequency and duration, early intervention before clinical symptoms emerge is considered essential, and hydrogen is presented as a candidate strategy warranting further investigation.

### Mechanism

H2 is proposed to selectively scavenge reactive oxygen species generated by cosmic radiation, thereby reducing oxidative damage to DNA and lipids before clinical manifestations develop.

## Bibliographic

- **Authors**: Schoenfeld MP, Ansari RR, Zakrajsek JF, Billiar TR, Toyoda Y, Wink DA, et al.
- **Journal**: Med Hypotheses
- **Year**: 2011
- **PMID**: [20851533](https://pubmed.ncbi.nlm.nih.gov/20851533/)
- **DOI**: [10.1016/j.mehy.2010.08.046](https://doi.org/10.1016/j.mehy.2010.08.046)
- **PMC**: [PMC7596391](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596391/)
- **Study type**: other
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 20851533. https://h2-papers.org/en/papers/20851533
> **Source**: PubMed PMID [20851533](https://pubmed.ncbi.nlm.nih.gov/20851533/)