# Therapeutic effects of hydrogen in animal models of Parkinson's disease.
> パーキンソン病動物モデルにおける分子状水素の効果に関する検討


## Abstract

Parkinson's disease (PD) is a refractory neurodegenerative disorder in which oxidative stress plays a central role in the apoptotic death of dopaminergic neurons, as established through experiments using the neurotoxins MPTP and 6-OHDA. This review examines the mechanistic pathway by which oxidative damage leads to irreversible neuronal loss and discusses evidence from two animal model systems showing that molecular hydrogen can reduce oxidative injury and attenuate degeneration of the nigrostriatal dopaminergic pathway. The findings suggest that hydrogen may offer a meaningful approach to limiting the onset and progression of PD.

### Mechanism

Molecular hydrogen selectively scavenges reactive oxygen species, including hydroxyl radicals, thereby reducing oxidative damage and apoptosis in dopaminergic neurons and preserving the nigrostriatal pathway in MPTP and 6-OHDA animal models.

## Bibliographic

- **Authors**: Fujita K, Nakabeppu Y, Noda M
- **Journal**: Parkinsons Dis
- **Year**: 2011
- **PMID**: [21687749](https://pubmed.ncbi.nlm.nih.gov/21687749/)
- **DOI**: [10.4061/2011/307875](https://doi.org/10.4061/2011/307875)
- **PMC**: [PMC3109337](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109337/)
- **Study type**: review
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 21687749. https://h2-papers.org/en/papers/21687749
> **Source**: PubMed PMID [21687749](https://pubmed.ncbi.nlm.nih.gov/21687749/)