# Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers.
> 急性紅斑性皮膚疾患に対する水素富化静脈内投与の症例報告と皮膚への水素到達動態に関する予備的検討


## Abstract

Four patients with acute erythematous skin diseases accompanied by fever and/or pain received intravenous infusions of 500 ml hydrogen-enriched fluid over 30 minutes for at least 3 days (one patient received a single infusion). Erythema and associated symptoms resolved markedly in all cases without recurrence. No adverse changes in physiological parameters or blood chemistry were detected. To characterize H2 delivery kinetics to the skin, two volunteers underwent serial blood sampling and leg-surface air collection during and after either intravenous or inhalation H2 administration, analyzed immediately by gas chromatography. Blood H2 levels rose rapidly upon inhalation and declined slowly after cessation, particularly in venous blood. Air H2 concentration at the skin surface changed even more gradually, suggesting that the skin may act as a slowly desaturating reservoir that prolongs local H2 delivery beyond the administration period.

### Mechanism

H2 appears to accumulate in skin tissue as a slowly desaturating reservoir, sustaining local delivery to the skin surface even after systemic administration has ended, potentially via hydroxyl radical scavenging.

## Bibliographic

- **Authors**: Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Nakazawa J, et al.
- **Journal**: Med Gas Res
- **Year**: 2012 (2012-05-20)
- **PMID**: [22607973](https://pubmed.ncbi.nlm.nih.gov/22607973/)
- **DOI**: [10.1186/2045-9912-2-14](https://doi.org/10.1186/2045-9912-2-14)
- **PMC**: [PMC3407032](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407032/)
- **Study type**: human case report
- **Delivery route**: mixed routes
- **Effect reported**: positive

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

---

> **Cite as**: H2 Papers — PMID 22607973. https://h2-papers.org/en/papers/22607973
> **Source**: PubMed PMID [22607973](https://pubmed.ncbi.nlm.nih.gov/22607973/)