# Hydrogen-rich water affected blood alkalinity in physically active men.
> 水素水の摂取が身体活動的な男性の動脈血アルカリ度に与える影響


## Abstract

A randomized, double-blind, placebo-controlled trial enrolled 52 healthy physically active men to evaluate 14-day oral intake of 2 L/day of hydrogen-rich water (HRW) versus tap water on arterial blood acid-base parameters. Arterial blood pH, bicarbonate concentration, and partial pressure of carbon dioxide were assessed at rest and after exercise on day 0 and day 14. After the 14-day period, fasting arterial pH rose by 0.04 (95% CI: 0.01–0.08; p < 0.001) and post-exercise pH by 0.07 (95% CI: 0.01–0.10; p = 0.03) in the HRW group. Fasting bicarbonate levels were significantly elevated compared with pre-intervention values (30.5 ± 1.9 vs. 28.3 ± 2.3 mEq/L; p < 0.0001). No participants withdrew and no adverse effects were reported, supporting the safety and alkalizing potential of HRW in this population.

### Mechanism

Oral hydrogen-rich water intake elevated bicarbonate concentrations in arterial blood, raising pH both at rest and after exercise, suggesting a buffering effect against exercise-induced metabolic acidosis.

## Bibliographic

- **Authors**: Ostojic SM, Stojanovic MD
- **Journal**: Res Sports Med
- **Year**: 2014
- **PMID**: [24392771](https://pubmed.ncbi.nlm.nih.gov/24392771/)
- **DOI**: [10.1080/15438627.2013.852092](https://doi.org/10.1080/15438627.2013.852092)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 24392771. https://h2-papers.org/en/papers/24392771
> **Source**: PubMed PMID [24392771](https://pubmed.ncbi.nlm.nih.gov/24392771/)