# Molecular hydrogen in sports medicine: new therapeutic perspectives.
> スポーツ医学における分子状水素：運動誘発性酸化ストレスおよびスポーツ傷害への応用可能性に関するレビュー


## Abstract

Molecular hydrogen (H2) has attracted growing scientific interest as a bioactive molecule with antioxidant, anti-inflammatory, and anti-apoptotic properties. Evidence from both animal models and human studies indicates beneficial effects in oxidative stress-related conditions including diabetes mellitus, brainstem infarction, rheumatoid arthritis, and neurodegenerative disorders. More recent investigations have revealed that H2 influences cell signal transduction and may act as an alkalizing agent, broadening its potential clinical relevance. This review consolidates current research on the clinical use of H2, with particular emphasis on its possible role in addressing exercise-induced oxidative stress, sports-related injuries, and exercise performance enhancement. The authors highlight how these newly identified mechanisms could expand the scope of H2 application within sports medicine.

### Mechanism

H2 selectively scavenges reactive oxygen species, particularly hydroxyl radicals, while also modulating cell signaling pathways and exerting an alkalizing effect on body fluids, collectively contributing to its cytoprotective actions.

## Bibliographic

- **Authors**: Ostojic SM
- **Journal**: Int J Sports Med
- **Year**: 2015
- **PMID**: [25525953](https://pubmed.ncbi.nlm.nih.gov/25525953/)
- **DOI**: [10.1055/s-0034-1395509](https://doi.org/10.1055/s-0034-1395509)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 25525953. https://h2-papers.org/en/papers/25525953
> **Source**: PubMed PMID [25525953](https://pubmed.ncbi.nlm.nih.gov/25525953/)