# Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.
> 分子状水素による乾癬関連関節炎および皮膚病変の改善：3症例の報告


## Abstract

Psoriasis is a chronic inflammatory skin condition driven by infiltrating immune cells and pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17. This case series examined the effects of molecular hydrogen (H2), a reactive oxygen species scavenger, on three patients with psoriasis-associated arthritis and skin lesions. Three delivery routes were employed: intravenous infusion of 1 ppm H2-containing saline, inhalation of 3% H2 gas, and oral intake of high-concentration hydrogen water (5–7 ppm). Disease activity was evaluated using the DAS28 score (C-reactive protein-based) and the Psoriasis Area and Severity Index (PASI). Across all three cases and regardless of delivery method, both DAS28 and PASI scores declined during H2 administration, and skin lesions nearly resolved by the end of the observation period. Cytokine analysis revealed reductions in IL-6 in Cases 1 and 2, and decreases in IL-17 and TNF-α in Case 1. These findings suggest that H2 administration may suppress psoriatic inflammation through ROS scavenging mechanisms.

### Mechanism

H2 is proposed to selectively neutralize hydroxyl radicals and peroxynitrite, thereby suppressing the immunogenic inflammatory cascade in psoriasis and reducing downstream cytokine production including TNF-α, IL-6, and IL-17.

## Bibliographic

- **Authors**: Ishibashi T, Ichikawa M, Sato B, Shibata S, Hara Y, Naritomi Y, et al.
- **Journal**: Mol Med Rep
- **Year**: 2015
- **PMID**: [25936373](https://pubmed.ncbi.nlm.nih.gov/25936373/)
- **DOI**: [10.3892/mmr.2015.3707](https://doi.org/10.3892/mmr.2015.3707)
- **Study type**: human case report
- **Delivery route**: mixed routes
- **Effect reported**: positive
- **H2 concentration**: 3%

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 25936373. https://h2-papers.org/en/papers/25936373
> **Source**: PubMed PMID [25936373](https://pubmed.ncbi.nlm.nih.gov/25936373/)