# Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation.
> 水素分子の摂取方法：飲水・注射・吸入における簡便かつ安全なデバイスの開発と水素濃度変化の検討


## Abstract

This study developed practical and safe devices supporting three distinct routes of molecular hydrogen (H2) administration: oral ingestion of super-saturated H2 water, intravenous drip infusion of H2-enriched saline, and inhalation of H2 gas. Temporal changes in H2 concentration were measured for each device to generate reference data useful for researchers. The work was motivated by observations that H2 is sometimes administered clinically without adequate safety protocols. The resulting data are intended to support the advancement of both non-clinical and clinical H2 research.

### Mechanism

H2 concentration changes over time were experimentally measured for each of the three delivery devices—drinking, intravenous infusion, and inhalation—to establish reproducible and safe administration conditions.

## Bibliographic

- **Authors**: Kurokawa R, Seo T, Sato B, Hirano S, Sato F
- **Journal**: Med Gas Res
- **Year**: 2015
- **PMID**: [26504515](https://pubmed.ncbi.nlm.nih.gov/26504515/)
- **DOI**: [10.1186/s13618-015-0034-2](https://doi.org/10.1186/s13618-015-0034-2)
- **PMC**: [PMC4620630](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620630/)
- **Study type**: other
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 26504515. https://h2-papers.org/en/papers/26504515
> **Source**: PubMed PMID [26504515](https://pubmed.ncbi.nlm.nih.gov/26504515/)