# [Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases].
> 水素医学の起源・発展と多様な疾患への応用可能性


## Abstract

This review article, authored by Ohta S and published in the Journal of the Japanese Biochemical Society, surveys the historical background, scientific development, and prospective applications of molecular hydrogen (H2) in medicine and disease prevention. The article traces how H2 research evolved from foundational observations of its antioxidant and anti-inflammatory properties to broader investigations spanning numerous pathological conditions. The scope encompasses both basic mechanistic insights and translational perspectives, positioning H2 as a candidate agent for addressing oxidative stress-related disorders across a wide disease spectrum.

### Mechanism

The central mechanism discussed involves selective scavenging of reactive oxygen species by molecular hydrogen, leading to attenuation of oxidative stress and inflammatory responses across various disease models.

## Bibliographic

- **Authors**: Ohta S
- **Journal**: Seikagaku
- **Year**: 2015
- **PMID**: [26571560](https://pubmed.ncbi.nlm.nih.gov/26571560/)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 26571560. https://h2-papers.org/en/papers/26571560
> **Source**: PubMed PMID [26571560](https://pubmed.ncbi.nlm.nih.gov/26571560/)