# Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer.
> 高脂肪食誘発性肥満ラットにおけるコーラルカルシウムハイドライドの肝脂肪蓄積抑制効果：ミトコンドリア機能改善とフェーズII酵素誘導


## Abstract

A solid molecular hydrogen carrier derived from coral calcium, designated CCH, was administered to rats with high-fat-diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) for 13 weeks. CCH produced hydrogen continuously both in vivo and in vitro. Compared with untreated HFD controls, CCH-supplemented animals showed reduced body weight gain and improved glucose and lipid metabolism without changes in food or water consumption. Hepatic lipid accumulation was markedly diminished. At the mechanistic level, CCH restored mitochondrial function impaired by HFD feeding, lowered markers of oxidative stress, and upregulated phase II detoxification enzymes. These findings indicate that sustained hydrogen release from CCH may underlie its protective effects on hepatic steatosis and metabolic disturbances in diet-induced obesity.

### Mechanism

CCH continuously releases molecular hydrogen in vivo, scavenging reactive oxygen species, activating phase II detoxification enzymes, and preserving mitochondrial function, collectively reducing hepatic lipid accumulation in HFD-fed rats.

## Bibliographic

- **Authors**: Hou C, Wang Y, Zhu E, Yan C, Zhao L, Wang X, et al.
- **Journal**: Biochem Pharmacol
- **Year**: 2016 (2016-03-01)
- **PMID**: [26774456](https://pubmed.ncbi.nlm.nih.gov/26774456/)
- **DOI**: [10.1016/j.bcp.2015.12.020](https://doi.org/10.1016/j.bcp.2015.12.020)
- **Study type**: animal study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 26774456. https://h2-papers.org/en/papers/26774456
> **Source**: PubMed PMID [26774456](https://pubmed.ncbi.nlm.nih.gov/26774456/)