# Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study.
> 水素水飲用が非外科的歯周治療に与える付加的効果：歯周炎改善に関するパイロット研究


## Abstract

Oxidative stress contributes to the development and progression of periodontitis. This pilot study enrolled 13 patients with periodontitis (3 women, 10 men) assigned to either a control group (n=6) or a hydrogen-rich water (HW) group (n=7). HW group participants consumed hydrogen-rich water 4–5 times daily over 8 weeks, while all participants underwent non-surgical periodontal procedures at weeks 2–4. Oral assessments and serum oxidative stress measurements were conducted at baseline and at weeks 2, 4, and 8. No significant intergroup differences in periodontal status were observed at baseline. The HW group demonstrated significantly greater reductions in probing pocket depth and improvements in clinical attachment level compared with controls at all post-baseline time points (p<0.05). Additionally, serum total antioxidant capacity was significantly elevated at week 4 relative to baseline in the HW group (p<0.05). These findings suggest that hydrogen-rich water consumption augments the clinical outcomes of non-surgical periodontal procedures.

### Mechanism

Consumption of hydrogen-rich water elevated serum total antioxidant capacity, thereby reducing oxidative stress implicated in periodontal tissue destruction. This antioxidant enhancement is proposed to augment the clinical improvements achieved through non-surgical periodontal procedures.

## Bibliographic

- **Authors**: Azuma T, Yamane M, Ekuni D, Kawabata Y, Kataoka K, Kasuyama K, et al.
- **Journal**: Antioxidants (Basel)
- **Year**: 2015 (2015-07-09)
- **PMID**: [26783840](https://pubmed.ncbi.nlm.nih.gov/26783840/)
- **DOI**: [10.3390/antiox4030513](https://doi.org/10.3390/antiox4030513)
- **PMC**: [PMC4665424](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665424/)
- **Study type**: human observational study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

---

> **Cite as**: H2 Papers — PMID 26783840. https://h2-papers.org/en/papers/26783840
> **Source**: PubMed PMID [26783840](https://pubmed.ncbi.nlm.nih.gov/26783840/)