# Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease.
> 水素豊富水摂取による慢性移植片対宿主病の1症例報告


## Abstract

Chronic graft-versus-host disease (cGVHD) is a serious complication following allogeneic hematopoietic stem cell transplantation, with inflammation and fibrosis identified as central pathogenic mechanisms. Molecular hydrogen possesses anti-inflammatory, antioxidant, and anti-fibrotic properties, suggesting potential relevance to cGVHD pathophysiology. This case report describes a patient with severe cGVHD who consumed hydrogen-rich water and experienced notable clinical improvement. The authors propose that oral intake of hydrogen-rich water may represent a safe and potentially beneficial approach for managing this difficult condition, warranting further investigation in controlled settings.

### Mechanism

Molecular hydrogen's anti-inflammatory, antioxidant, and anti-fibrotic properties may suppress the inflammation and fibrosis that underlie cGVHD pathogenesis.

## Bibliographic

- **Authors**: Qian L, Shen J
- **Journal**: Med Gas Res
- **Year**: 2016
- **PMID**: [27867488](https://pubmed.ncbi.nlm.nih.gov/27867488/)
- **DOI**: [10.4103/2045-9912.191366](https://doi.org/10.4103/2045-9912.191366)
- **PMC**: [PMC5110137](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110137/)
- **Study type**: human case report
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 27867488. https://h2-papers.org/en/papers/27867488
> **Source**: PubMed PMID [27867488](https://pubmed.ncbi.nlm.nih.gov/27867488/)