# Should hydrogen therapy be included in a musculoskeletal medicine routine?
> 筋骨格系医学における水素の応用可能性に関する考察


## Abstract

Molecular hydrogen (H2) has attracted growing attention as a novel biomedical agent. Multiple clinical trials have documented favorable outcomes in conditions such as neuromuscular disorders, cardiometabolic diseases, and cancer, with anti-inflammatory and antioxidant actions identified as primary mechanisms. This review examines the medicinal properties of H2 specifically within the context of musculoskeletal medicine, aiming to offer an updated and practical overview for clinicians and health professionals active in this specialty area.

### Mechanism

H2 is proposed to exert protective effects on musculoskeletal tissues primarily through selective scavenging of reactive oxygen species and suppression of pro-inflammatory cytokine signaling.

## Bibliographic

- **Authors**: Ostojic SM
- **Journal**: F1000Res
- **Year**: 2016
- **PMID**: [28003879](https://pubmed.ncbi.nlm.nih.gov/28003879/)
- **DOI**: [10.12688/f1000research.9758.1](https://doi.org/10.12688/f1000research.9758.1)
- **PMC**: [PMC5147523](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147523/)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 28003879. https://h2-papers.org/en/papers/28003879
> **Source**: PubMed PMID [28003879](https://pubmed.ncbi.nlm.nih.gov/28003879/)