# Molecular hydrogen: a therapeutic antioxidant and beyond.
> 分子状水素：抗酸化作用を超えた多面的な生物学的効果に関するレビュー


## Abstract

Research on molecular hydrogen (H2) in medicine has expanded substantially following an early landmark study demonstrating antioxidant and cytoprotective properties in a focal stroke animal model. Accumulated evidence indicates that H2 holds promise across a broad range of disease conditions, and the mechanistic basis extends well beyond simple hydroxyl radical scavenging. The absence of toxicity even at elevated concentrations, combined with rapid diffusion across cellular membranes, supports the feasibility of translating H2-based interventions into clinical settings for human patients.

### Mechanism

H2 exerts cytoprotective effects through mechanisms beyond selective hydroxyl radical scavenging. Its rapid membrane diffusion and absence of toxicity at high concentrations underpin its broad biological activity.

## Bibliographic

- **Authors**: Huang L
- **Journal**: Med Gas Res
- **Year**: 2016
- **PMID**: [28217294](https://pubmed.ncbi.nlm.nih.gov/28217294/)
- **DOI**: [10.4103/2045-9912.196904](https://doi.org/10.4103/2045-9912.196904)
- **PMC**: [PMC5223313](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223313/)
- **Study type**: review
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 28217294. https://h2-papers.org/en/papers/28217294
> **Source**: PubMed PMID [28217294](https://pubmed.ncbi.nlm.nih.gov/28217294/)