# Effects of hydrogen rich water on prolonged intermittent exercise.
> 水素水の2週間摂取が持続的インターバル運動中の反復スプリントパフォーマンスに与える影響


## Abstract

A crossover single-blind controlled trial enrolled 8 trained male cyclists (mean age 41 years, VO2max 52.6 mL·kg⁻¹·min⁻¹) who consumed either 2 liters per day of hydrogen-rich water (HRW; pH 9.8, ORP −180 mV, free hydrogen 450 ppb) or placebo water (pH 7.6, ORP +230 mV, 0 ppb hydrogen) for two-week periods. A 30-minute intermittent cycling protocol comprising 10 blocks of mixed-intensity efforts and 16-second all-out sprints was performed at baseline and after each intervention period. In the placebo condition, peak power output (PPO) declined significantly during the 8th and 9th sprints (relative decrease up to −12±5%, P<0.006), whereas PPO remained stable throughout in the HRW condition. Mean power, fatigue index, and time to peak power did not differ between groups. Blood lactate rose and both pH and bicarbonate fell progressively in both conditions, with no between-group differences in these acid-base variables. The findings suggest that sustained HRW intake may help preserve PPO during repeated exhaustive sprints.

### Mechanism

The mechanism remains unclear; although HRW is hypothesized to influence acid-base homeostasis, no significant between-group differences in blood lactate, pH, or bicarbonate were observed, leaving the basis for preserved peak power output unexplained.

## Bibliographic

- **Authors**: Da Ponte A, Giovanelli N, Nigris D, Lazzer S
- **Journal**: J Sports Med Phys Fitness
- **Year**: 2018
- **PMID**: [28474871](https://pubmed.ncbi.nlm.nih.gov/28474871/)
- **DOI**: [10.23736/S0022-4707.17.06883-9](https://doi.org/10.23736/S0022-4707.17.06883-9)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: mixed

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 28474871. https://h2-papers.org/en/papers/28474871
> **Source**: PubMed PMID [28474871](https://pubmed.ncbi.nlm.nih.gov/28474871/)