# Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.
> 中年過体重女性における水素摂取が体組成・代謝プロファイル・ミトコンドリア機能に与える影響


## Abstract

A double-blind, placebo-controlled crossover pilot trial enrolled ten middle-aged overweight women to assess oral hydrogen supplementation via hydrogen-generating mineral caplets delivering approximately 6 ppm H2 per day over 4 weeks. Body fat percentage declined by 3.2% in the H2 group versus 0.9% in the placebo group (P=0.05), and the arm fat index fell by 9.7% versus 6.0% (P=0.01). Serum triglycerides decreased by 21.3% with H2 compared to 6.5% with placebo (P=0.04), while other lipid parameters remained unchanged. Fasting insulin levels dropped 5.4% following H2 administration, whereas placebo was associated with a 29.3% increase (P=0.01). Body weight, BMI, and circumference measurements showed no significant between-group differences. These findings suggest that orally delivered hydrogen may favorably influence fat distribution and insulin sensitivity in overweight individuals.

### Mechanism

Orally administered hydrogen-generating minerals appear to modulate lipid metabolism and insulin signaling, resulting in reductions in body fat percentage, serum triglycerides, and fasting insulin levels, potentially through mitochondrial function improvement.

## Bibliographic

- **Authors**: Korovljev D, Trivic T, Drid P, Ostojic SM
- **Journal**: Ir J Med Sci
- **Year**: 2018
- **PMID**: [28560519](https://pubmed.ncbi.nlm.nih.gov/28560519/)
- **DOI**: [10.1007/s11845-017-1638-4](https://doi.org/10.1007/s11845-017-1638-4)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: mixed

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 28560519. https://h2-papers.org/en/papers/28560519
> **Source**: PubMed PMID [28560519](https://pubmed.ncbi.nlm.nih.gov/28560519/)