# Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration.
> 急性および慢性神経疾患における分子状水素の神経保護効果：作用機序と投与経路に関するレビュー


## Abstract

Reactive oxygen species-induced oxidative stress is recognized as a central driver of neuronal damage across a spectrum of conditions, from acute neurological emergencies to chronic neurodegenerative disorders. Molecular hydrogen has been well characterized as a selective scavenger of hydroxyl radicals and peroxynitrite. Both preclinical and clinical investigations have documented neuroprotective outcomes associated with hydrogen administration. This review examines the evidence for hydrogen's effects in acute neuronal injury and neurodegenerative disease contexts, as well as the various routes through which hydrogen can be delivered, including hydrogen-enriched drinking water, which may hold particular promise for symptom reduction in acute conditions and prevention in neurodegenerative settings.

### Mechanism

Molecular hydrogen selectively neutralizes hydroxyl radicals and peroxynitrite, thereby reducing reactive oxygen species-mediated oxidative damage in neuronal tissues.

## Bibliographic

- **Authors**: Dohi K, Satoh K, Miyamoto K, Momma S, Fukuda K, Higuchi R, et al.
- **Journal**: J Clin Biochem Nutr
- **Year**: 2017
- **PMID**: [28751802](https://pubmed.ncbi.nlm.nih.gov/28751802/)
- **DOI**: [10.3164/jcbn.16-87](https://doi.org/10.3164/jcbn.16-87)
- **PMC**: [PMC5525017](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525017/)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 28751802. https://h2-papers.org/en/papers/28751802
> **Source**: PubMed PMID [28751802](https://pubmed.ncbi.nlm.nih.gov/28751802/)