# Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
> 水素豊富水がSMP30ノックアウトマウスにおける喫煙誘発性肺気腫を抑制する


## Abstract

Using SMP30 knockout (SMP30-KO) mice as a COPD model, this study examined whether hydrogen-rich pure water could mitigate lung damage caused by 8 weeks of cigarette smoke (CS) exposure. Oral administration of hydrogen-rich water led to measurable improvements in mean linear intercept and destructive index, along with restoration of static lung compliance. Oxidative DNA damage markers—phosphorylated histone H2AX and 8-hydroxy-2'-deoxyguanosine—were significantly reduced, as were cellular senescence markers including cyclin-dependent kinase inhibitor 2A (p16), cyclin-dependent kinase inhibitor 1 (p21), and β-galactosidase. These findings indicate that molecular hydrogen attenuates CS-induced emphysematous changes by suppressing oxidative DNA damage and stress-induced premature senescence in lung tissue, suggesting a potential preventive role for hydrogen-rich water in COPD-related pathology.

### Mechanism

Molecular hydrogen selectively scavenges hydroxyl radicals generated by cigarette smoke, thereby reducing oxidative DNA damage (γ-H2AX, 8-OHdG) and suppressing stress-induced premature cellular senescence (p16, p21, β-galactosidase upregulation) in lung tissue, which collectively attenuates emphysematous remodeling.

## Bibliographic

- **Authors**: Suzuki Y, Sato T, Sugimoto M, Baskoro H, Karasutani K, Mitsui A, et al.
- **Journal**: Biochem Biophys Res Commun
- **Year**: 2017 (2017-10-07)
- **PMID**: [28807355](https://pubmed.ncbi.nlm.nih.gov/28807355/)
- **DOI**: [10.1016/j.bbrc.2017.08.035](https://doi.org/10.1016/j.bbrc.2017.08.035)
- **Study type**: animal study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 28807355. https://h2-papers.org/en/papers/28807355
> **Source**: PubMed PMID [28807355](https://pubmed.ncbi.nlm.nih.gov/28807355/)