# Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury.
> 分子状水素による酸化ストレス誘発性放射線障害軽減の可能性


## Abstract

This review examines the capacity of molecular hydrogen (H2) to scavenge reactive oxygen and nitrogen species in artificial radical-generating systems. In rat cardiac tissue, in vivo H2 administration produced significant elevations in superoxide dismutase activity and pAKT, a marker of cell survival signaling. Radiation-induced lipid peroxidation in rats was substantially reduced by H2 pre-treatment. The authors propose that Nrf2 (nuclear factor erythroid 2-related factor 2) pathway activation underlies these protective effects, promoting endogenous antioxidant defenses while suppressing apoptosis and inflammatory responses. These findings position H2 as a candidate agent for mitigating radiation-associated oxidative damage.

### Mechanism

H2 is proposed to activate the Nrf2 pathway, upregulating endogenous antioxidant enzymes such as superoxide dismutase, reducing lipid peroxidation, and suppressing apoptosis and inflammation, while also enhancing cell survival via pAKT signaling.

## Bibliographic

- **Authors**: Kura B, Bagchi A, Singal PK, Barancik M, LeBaron TW, Valachova K, et al.
- **Journal**: Can J Physiol Pharmacol
- **Year**: 2019
- **PMID**: [30543459](https://pubmed.ncbi.nlm.nih.gov/30543459/)
- **DOI**: [10.1139/cjpp-2018-0604](https://doi.org/10.1139/cjpp-2018-0604)
- **Study type**: review
- **Delivery route**: injection / infusion
- **Effect reported**: positive

## Delivery context

Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).

## Safety notes

Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

---

> **Cite as**: H2 Papers — PMID 30543459. https://h2-papers.org/en/papers/30543459
> **Source**: PubMed PMID [30543459](https://pubmed.ncbi.nlm.nih.gov/30543459/)