# Effects of hydrogen-rich water in a rat model of polycystic kidney disease.
> 多発性嚢胞腎ラットモデルにおける水素水摂取の影響に関する検討


## Abstract

Forty PCK rats aged 5 weeks were randomly divided into four groups receiving purified water, sugar-supplemented water, hydrogen-rich water, or sugar-supplemented hydrogen-rich water from 5 to 15 weeks of age. Sugar-supplemented groups showed significantly higher water intake compared with controls, yet serum creatinine levels did not differ significantly across groups. Kidney weight relative to body weight was significantly lower in the sugar-water group than in controls, whereas hydrogen-rich water groups showed significantly higher kidney weights than the sugar-water group. The ratio of cyst cross-sectional area to total kidney area did not differ significantly among any groups. These findings indicate that large-volume hydrogen-rich water consumption did not produce a statistically significant advantage over plain water in limiting cyst enlargement in PCK rats. The authors note that modifications to administration route or duration might reveal effects not detected in the current protocol.

### Mechanism

Hydrogen-rich water is known to reduce oxidative stress and may benefit kidney tissue; however, in this PCK rat model, no significant suppression of cyst enlargement was observed compared with plain water, regardless of intake volume.

## Bibliographic

- **Authors**: Yamasaki M, Miyazono M, Yoshihara M, Suenaga A, Mizuta M, Fukuda M, et al.
- **Journal**: PLoS One
- **Year**: 2019
- **PMID**: [31013316](https://pubmed.ncbi.nlm.nih.gov/31013316/)
- **DOI**: [10.1371/journal.pone.0215766](https://doi.org/10.1371/journal.pone.0215766)
- **PMC**: [PMC6478309](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478309/)
- **Study type**: animal study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: null

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 31013316. https://h2-papers.org/en/papers/31013316
> **Source**: PubMed PMID [31013316](https://pubmed.ncbi.nlm.nih.gov/31013316/)