# Recent Advances in Studies of Molecular Hydrogen against Sepsis.
> 敗血症に対する水素分子の研究における最近の進展


## Abstract

Sepsis is a life-threatening syndrome arising from a dysregulated host response to infection, leading to multi-organ dysfunction. Molecular hydrogen has attracted attention as a novel antioxidant capable of scavenging free radicals, with documented efficacy across conditions including infection, trauma, ischemia-reperfusion injury, metabolic disorders, and malignancies. This review examines the biological actions of molecular hydrogen relevant to sepsis, encompassing anti-inflammatory, antioxidative, anti-apoptotic, anti-shock, and autophagy-regulatory effects, all of which may reduce organ and barrier damage associated with sepsis. The current state of knowledge regarding underlying signaling pathways is discussed, and the review aims to provide a mechanistic framework for future investigation into hydrogen's role in sepsis management.

### Mechanism

Molecular hydrogen is proposed to mitigate sepsis-induced organ and barrier injury by scavenging reactive oxygen species, suppressing inflammatory signaling cascades, and modulating apoptotic and autophagic pathways.

## Bibliographic

- **Authors**: Qiu P, Liu Y, Zhang JH
- **Journal**: Int J Biol Sci
- **Year**: 2019
- **PMID**: [31223285](https://pubmed.ncbi.nlm.nih.gov/31223285/)
- **DOI**: [10.7150/ijbs.30741](https://doi.org/10.7150/ijbs.30741)
- **PMC**: [PMC6567800](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567800/)
- **Study type**: review
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 31223285. https://h2-papers.org/en/papers/31223285
> **Source**: PubMed PMID [31223285](https://pubmed.ncbi.nlm.nih.gov/31223285/)