# Micro/Nanomaterials-Augmented Hydrogen Therapy.
> マイクロ・ナノ材料を活用した水素医療の増強戦略に関するレビュー


## Abstract

Molecular hydrogen exhibits bio-reductive and homeostatic properties that confer beneficial effects against oxidative stress- and inflammation-related conditions. Unlike gaseous transmitters such as NO, CO, and H2S, H2 does not interfere with oxygen transport by erythrocytes, making high-concentration exposure relatively safe. However, its low aqueous solubility and non-directional diffusion limit site-specific efficacy. This review introduces the concept of hydrogen nanomedicine, systematically organizing approaches that employ functional micro/nanomaterials to achieve targeted hydrogen delivery, controlled release, and nanocatalytic or multimodal enhancement of hydrogen efficacy. These strategies are presented as a framework for advancing the investigation of hydrogen's effects on inflammation-related diseases.

### Mechanism

H2 exerts bio-reductive effects and modulates homeostatic pathways to suppress oxidative stress and inflammation. Functional micro/nanomaterials enable targeted delivery and controlled release, increasing local H2 concentration and enhancing efficacy at disease sites.

## Bibliographic

- **Authors**: Zhou G, Goshi E, He Q
- **Journal**: Adv Healthc Mater
- **Year**: 2019
- **PMID**: [31267691](https://pubmed.ncbi.nlm.nih.gov/31267691/)
- **DOI**: [10.1002/adhm.201900463](https://doi.org/10.1002/adhm.201900463)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 31267691. https://h2-papers.org/en/papers/31267691
> **Source**: PubMed PMID [31267691](https://pubmed.ncbi.nlm.nih.gov/31267691/)