# Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.
> 水素による代謝経路スイッチの逆転を介したアレルギー性気道炎症の抑制機序


## Abstract

This observational and experimental study investigated whether molecular hydrogen exerts anti-inflammatory effects through modulation of energy metabolic reprogramming. In monocytes from asthmatic patients and in lungs of ovalbumin-sensitized mice, elevated lactate production and glycolytic enzyme activities were accompanied by reduced ATP output and diminished mitochondrial respiratory chain complex I and III activities, indicating a shift from oxidative phosphorylation to aerobic glycolysis. Hydrogen administration to sensitized mice reversed this metabolic switch, suppressed upregulation of glycolytic enzymes and hypoxia-inducible factor-1α, and restored expression of mitochondrial respiratory chain complexes and PGC-1α. Additionally, hydrogen counteracted the downregulation of sirtuins 1, 3, 5, and 6. These findings suggest that hydrogen modulates energy metabolic reprogramming at multiple regulatory levels, thereby reducing allergic airway inflammation.

### Mechanism

Hydrogen suppresses HIF-1α and glycolytic enzyme upregulation while restoring PGC-1α and sirtuins 1, 3, 5, and 6 expression, thereby reversing the metabolic shift from aerobic glycolysis back to mitochondrial oxidative phosphorylation and reducing airway inflammation.

## Bibliographic

- **Authors**: Niu Y, Nie Q, Dong L, Zhang JH, Liu SJ, Song W, et al.
- **Journal**: Sci Rep
- **Year**: 2020 (2020-02-06)
- **PMID**: [32029879](https://pubmed.ncbi.nlm.nih.gov/32029879/)
- **DOI**: [10.1038/s41598-020-58999-0](https://doi.org/10.1038/s41598-020-58999-0)
- **PMC**: [PMC7005324](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005324/)
- **Study type**: human observational study
- **Delivery route**: mixed routes
- **Effect reported**: positive

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 32029879. https://h2-papers.org/en/papers/32029879
> **Source**: PubMed PMID [32029879](https://pubmed.ncbi.nlm.nih.gov/32029879/)