# Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.
> プロサッカー選手における軽度外傷性脳損傷後の水素産生製剤の口腔粘膜投与：症例報告


## Abstract

A professional soccer player who sustained a sport-related mild traumatic brain injury (TBI) received a hydrogen-producing dissolving tablet via buccal (oral transmucosal) administration beginning approximately 15 minutes post-injury, with doses repeated every 2 hours over a 24-hour period. Assessment using the Sport Concussion Assessment Tool 2 (SCAT2) showed improvement from a baseline score of 68 (indicating severe disruption) to 84 (mild disruption) at the 24-hour follow-up. No adverse effects were reported throughout the intervention period. The findings suggest that molecular hydrogen, known for its ability to readily penetrate brain tissue, may offer neuroprotective benefits as an early-stage intervention following mild TBI, representing a potentially useful option where conventional approaches are limited.

### Mechanism

Molecular hydrogen readily crosses into brain tissue and is thought to exert neuroprotective effects, potentially reducing neurological dysfunction following traumatic injury through antioxidant and anti-inflammatory mechanisms.

## Bibliographic

- **Authors**: Javorac D, Stajer V, Ostojic SM
- **Journal**: F1000Res
- **Year**: 2019
- **PMID**: [32595937](https://pubmed.ncbi.nlm.nih.gov/32595937/)
- **DOI**: [10.12688/f1000research.19739.1](https://doi.org/10.12688/f1000research.19739.1)
- **PMC**: [PMC7308882](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308882/)
- **Study type**: human case report
- **Delivery route**: topical application
- **Effect reported**: positive

## Delivery context

Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 32595937. https://h2-papers.org/en/papers/32595937
> **Source**: PubMed PMID [32595937](https://pubmed.ncbi.nlm.nih.gov/32595937/)