# Hydrogenases and the Role of Molecular Hydrogen in Plants.
> 植物におけるヒドロゲナーゼと分子状水素の役割に関するレビュー


## Abstract

Molecular hydrogen (H2) has been proposed to exert beneficial effects across a wide range of organisms, including plants. Hydrogenases, enzymes that catalyze the reversible oxidation of H2, are present in numerous species including plants. At the cellular level, H2 selectively neutralizes specific reactive oxygen species (ROS) and reactive nitrogen species (RNS), notably hydroxyl radicals and peroxynitrite. This review examines the function of hydrogenases within the broader context of redox signaling, noting that enzyme activity can be modulated through covalent modification of thiol groups. Using a bioinformatics approach, the authors investigated whether nitric oxide (NO)-targeted motifs exist in hydrogenase sequences and concluded that metal prosthetic groups are more likely targets of inhibition. The review also summarizes methods of H2 application to plants and documents reported improvements in plant growth and stress responses, calling for future research to elucidate the underlying molecular mechanisms.

### Mechanism

H2 selectively scavenges hydroxyl radicals and peroxynitrite among ROS/RNS. Hydrogenase activity may be regulated via redox signaling molecules targeting metal prosthetic groups rather than thiol motifs.

## Bibliographic

- **Authors**: Russell G, Zulfiqar F, Hancock JT
- **Journal**: Plants (Basel)
- **Year**: 2020 (2020-09-02)
- **PMID**: [32887396](https://pubmed.ncbi.nlm.nih.gov/32887396/)
- **DOI**: [10.3390/plants9091136](https://doi.org/10.3390/plants9091136)
- **PMC**: [PMC7569912](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569912/)
- **Study type**: review
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 32887396. https://h2-papers.org/en/papers/32887396
> **Source**: PubMed PMID [32887396](https://pubmed.ncbi.nlm.nih.gov/32887396/)