# Molecular Hydrogen Application in Stroke: Bench to Bedside.
> 脳卒中における分子状水素の応用：基礎研究から臨床への展開


## Abstract

Stroke remains a leading contributor to global mortality and long-term disability, with few established interventions available. This review consolidates findings from both preclinical animal models and clinical investigations examining the effects of molecular hydrogen on stroke outcomes. The authors discuss neuroprotective mechanisms relevant to stroke pathology, positioning molecular hydrogen as a candidate medical gas with potential neurological applications. Both experimental evidence and early clinical data are synthesized to evaluate the translational prospects of hydrogen-based approaches in stroke.

### Mechanism

Molecular hydrogen is proposed to exert neuroprotection primarily through selective scavenging of highly reactive oxygen species such as hydroxyl radicals and peroxynitrite, thereby reducing oxidative damage in stroke-affected neural tissue.

## Bibliographic

- **Authors**: Huang L, Lenahan C, Boling W, Tang J, Zhang JH
- **Journal**: Curr Pharm Des
- **Year**: 2021
- **PMID**: [32940172](https://pubmed.ncbi.nlm.nih.gov/32940172/)
- **DOI**: [10.2174/1381612826666200917152316](https://doi.org/10.2174/1381612826666200917152316)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 32940172. https://h2-papers.org/en/papers/32940172
> **Source**: PubMed PMID [32940172](https://pubmed.ncbi.nlm.nih.gov/32940172/)