# Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.
> 皮膚疾患における分子状水素の役割と美容への影響に関するレビュー


## Abstract

The skin, as the body's largest organ, serves as a primary barrier against environmental, physical, chemical, and biological stressors. These stressors generate reactive oxygen and nitrogen species, and when oxidant production exceeds the skin's antioxidant defense capacity, oxidative stress and chronic inflammation ensue. Downstream consequences include collagen fiber degradation and impaired skin cell function, contributing to conditions such as psoriasis, atopic dermatitis, and skin aging. This review consolidates current evidence on the role of oxidative stress in dermatological pathogenesis and its effects on patients' quality of life and physical appearance. The potential of molecular hydrogen to counteract oxidative stress in skin-related conditions is examined, with findings suggesting it may represent a promising investigational approach for various dermatological disorders.

### Mechanism

Molecular hydrogen selectively scavenges reactive oxygen and nitrogen species, thereby reducing oxidative stress and chronic inflammation. This suppression is proposed to prevent collagen fiber degradation and preserve normal skin cell function in dermatological conditions.

## Bibliographic

- **Authors**: Bajgai J, Lee KJ, Rahman MH, Fadriquela A, Kim CS
- **Journal**: Curr Pharm Des
- **Year**: 2021
- **PMID**: [32981497](https://pubmed.ncbi.nlm.nih.gov/32981497/)
- **DOI**: [10.2174/1381612826666200925124235](https://doi.org/10.2174/1381612826666200925124235)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 32981497. https://h2-papers.org/en/papers/32981497
> **Source**: PubMed PMID [32981497](https://pubmed.ncbi.nlm.nih.gov/32981497/)