# Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.
> 膵炎に対する分子状水素の効果に関する最近の研究動向


## Abstract

Pancreatitis is an inflammatory pancreatic disorder involving acinar cell damage and aberrant trypsin release, which can progress to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The pathogenesis encompasses inflammatory cascades, disrupted autophagic flux, and endoplasmic reticulum stress (ERS). This review examines the biological properties of molecular hydrogen (H2) — notably its selective scavenging of reactive oxygen species and non-toxic metabolic profile — and surveys accumulating evidence that H2 may exert beneficial effects on pancreatitis through antioxidative, anti-inflammatory, anti-apoptotic, immunomodulatory, and molecular pathway-regulatory mechanisms. The authors discuss the current state of research and outline potential directions for future investigation and clinical application.

### Mechanism

H2 selectively neutralizes reactive oxygen species and is proposed to suppress pancreatitis pathology through anti-inflammatory, anti-apoptotic, immunomodulatory, and molecular signaling regulatory actions, potentially also involving modulation of autophagic flux and endoplasmic reticulum stress.

## Bibliographic

- **Authors**: Li Y, Li G, Suo L, Zhang JH
- **Journal**: Life Sci
- **Year**: 2021 (2021-01-01)
- **PMID**: [33148420](https://pubmed.ncbi.nlm.nih.gov/33148420/)
- **DOI**: [10.1016/j.lfs.2020.118641](https://doi.org/10.1016/j.lfs.2020.118641)
- **Study type**: review
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 33148420. https://h2-papers.org/en/papers/33148420
> **Source**: PubMed PMID [33148420](https://pubmed.ncbi.nlm.nih.gov/33148420/)