# Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder.
> ゲル型エマルションと水素発生粉末を組み合わせた水素水マスクパックの抗酸化活性評価


## Abstract

Hydrogen-generating powders were synthesized from zinc carbonate precursors at temperatures ranging from 400 to 700°C under a hydrogen atmosphere. Dissolved hydrogen concentrations were tracked over time using a dedicated meter. Antioxidant capacity was assessed via Oyaizu's method, hydroxyl radical scavenging rate, and ferric reducing antioxidant power (FRAP). A facial mask pack was then formulated by combining the optimized powder with a gel-type emulsion. In a clinical evaluation, participants using the hydrogen mask pack showed an 18.41% increase in skin density after 4 weeks, compared to 9.93% in the control group using a commercial product. The greater improvement in skin density observed in the experimental group was attributed to the capacity of molecular hydrogen to support recovery of the denatured outer skin layer.

### Mechanism

Molecular hydrogen is proposed to scavenge hydroxyl radicals and support structural recovery of the denatured skin layer, thereby contributing to increased skin density.

## Bibliographic

- **Authors**: Kwon HJ, Han SB, Park KW
- **Journal**: Int J Mol Sci
- **Year**: 2020 (2020-12-20)
- **PMID**: [33419292](https://pubmed.ncbi.nlm.nih.gov/33419292/)
- **DOI**: [10.3390/ijms21249731](https://doi.org/10.3390/ijms21249731)
- **PMC**: [PMC7766410](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766410/)
- **Study type**: human observational study
- **Delivery route**: topical application
- **Effect reported**: positive

## Delivery context

Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 33419292. https://h2-papers.org/en/papers/33419292
> **Source**: PubMed PMID [33419292](https://pubmed.ncbi.nlm.nih.gov/33419292/)