# A confined crosslinking strategy towards an intelligent organosilica-micellar hybrid drug delivery system.
> オルガノシリカ-ミセルハイブリッドナノシステムによる酸応答性薬物送達プラットフォームの構築


## Abstract

A confined crosslinking approach was developed to fabricate an intelligent hybrid nanocarrier combining organosilica and polymeric micelles. The system was assembled by hydrolyzing and condensing APTES silanes within Pluronic micelles, followed by Schiff base crosslinking with glutaraldehyde. The resulting docetaxel (DTX)-loaded nanoparticles exhibit pH-dependent size switching: approximately 25 nm at physiological pH (~7.4), expanding to ~250 nm under mildly acidic conditions (~6.5–7.0) via intramolecular hydrogen bond-driven aggregation, and subsequently disintegrating at endosomal pH (~5.0–6.2) through imine bond cleavage to release the payload. Auto-fluorescence generated within the system enables real-time tracking without additional labeling agents. This design strategy offers a framework for constructing stimuli-responsive, fluorescence-guided nanocarriers intended for tumor-targeted drug delivery.

### Mechanism

At physiological pH (~7.4), intramolecular hydrogen bonds maintain ~25 nm particle size. Mild acidity (~6.5–7.0) triggers aggregation to ~250 nm, while endosomal pH (~5.0–6.2) cleaves imine bonds, causing nanoparticle disintegration and controlled drug release.

## Bibliographic

- **Authors**: Qin X, Qin L, He J, Wang Q, Li Y, Niu D
- **Journal**: Biomater Sci
- **Year**: 2022 (2022-01-18)
- **PMID**: [34904973](https://pubmed.ncbi.nlm.nih.gov/34904973/)
- **DOI**: [10.1039/d1bm01485d](https://doi.org/10.1039/d1bm01485d)
- **Study type**: in vitro study
- **Delivery route**: in vitro
- **Effect reported**: positive

## Delivery context

This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 34904973. https://h2-papers.org/en/papers/34904973
> **Source**: PubMed PMID [34904973](https://pubmed.ncbi.nlm.nih.gov/34904973/)