# Molecular hydrogen is a potential protective agent in the management of acute lung injury.
> 急性肺傷害に対する分子状水素の保護的役割：メカニズムと臨床応用の可能性


## Abstract

Acute lung injury (ALI) and its severe manifestation, acute respiratory distress syndrome (ARDS), represent life-threatening conditions in critically ill patients. The global spread of COVID-19 has heightened the urgency for effective interventions targeting severe respiratory dysfunction. This review examines the biological actions of molecular hydrogen relevant to ALI pathophysiology, encompassing anti-inflammatory effects, antioxidant activity, modulation of autophagy, and regulation of cell death pathways. Evidence from multiple studies is synthesized to outline how these mechanisms may collectively reduce ALI severity. The authors also discuss the potential relevance of hydrogen-based approaches to COVID-19-associated lung damage, aiming to establish a scientific foundation for future clinical investigations in this area.

### Mechanism

Molecular hydrogen is proposed to mitigate ALI progression through anti-inflammatory and antioxidant actions, combined with modulation of autophagy and cell death pathways including apoptosis, thereby reducing lung tissue damage.

## Bibliographic

- **Authors**: Zhang YJ, Zhang JH, Fu Z
- **Journal**: Mol Med
- **Year**: 2022 (2022-03-03)
- **PMID**: [35240982](https://pubmed.ncbi.nlm.nih.gov/35240982/)
- **DOI**: [10.1186/s10020-022-00455-y](https://doi.org/10.1186/s10020-022-00455-y)
- **PMC**: [PMC8892414](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892414/)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 35240982. https://h2-papers.org/en/papers/35240982
> **Source**: PubMed PMID [35240982](https://pubmed.ncbi.nlm.nih.gov/35240982/)