# Emerging Trends and Hot Spots in Sepsis-Associated Encephalopathy Research From 2001 to 2021: A Bibliometric Analysis.
> 敗血症関連脳症研究における新興トレンドとホットスポット（2001〜2021年）：書誌計量学的解析


## Abstract

A bibliometric analysis was conducted on 1,582 publications related to sepsis-associated encephalopathy (SAE) indexed in the Web of Science Core Collection between 2001 and 2021. Using CiteSpace, VOSviewer, and Bibliometrix, co-citation cluster analysis and keyword co-occurrence mapping were applied to identify research patterns and emerging topics. The United States and China were the dominant contributing nations, with Vanderbilt University and the University of Pittsburgh occupying central positions in the collaboration network. Co-citation cluster analysis identified 'molecular hydrogen' as one of the notable cluster labels alongside critical illness, neuroinflammation, and blood-brain barrier dysfunction. Keyword burst detection further highlighted neuroinflammation, blood-brain barrier integrity, and mitochondrial dysfunction as the most active current research areas. These findings suggest that SAE research has progressively shifted toward mechanistic investigation of neurological injury, with molecular hydrogen emerging as a topic of interest within this field.

### Mechanism

Bibliometric cluster analysis identified neuroinflammation, blood-brain barrier disruption, and mitochondrial dysfunction as the principal mechanistic foci in SAE research, with molecular hydrogen appearing as a notable keyword cluster label over the 20-year period.

## Bibliographic

- **Authors**: Zhang YJ, Chen SL, Tian W, Zhu H, Li W, Dai W, et al.
- **Journal**: Front Med (Lausanne)
- **Year**: 2022
- **PMID**: [35295600](https://pubmed.ncbi.nlm.nih.gov/35295600/)
- **DOI**: [10.3389/fmed.2022.817351](https://doi.org/10.3389/fmed.2022.817351)
- **PMC**: [PMC8918530](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918530/)
- **Study type**: other
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

---

> **Cite as**: H2 Papers — PMID 35295600. https://h2-papers.org/en/papers/35295600
> **Source**: PubMed PMID [35295600](https://pubmed.ncbi.nlm.nih.gov/35295600/)