# Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality?
> 虚血後アルツハイマー型神経変性における分子状水素の神経保護：作用機序と臨床応用の可能性


## Abstract

This review synthesizes current knowledge on the neuroprotective actions of molecular hydrogen (H2) in the context of cerebral ischemia-induced neurodegeneration resembling Alzheimer's disease proteinopathy. Following ischemic brain injury, characteristic pathological features include pyramidal neuron loss in the hippocampal CA1 region, disruption of the blood-brain barrier, neuroinflammation, amyloid and tau protein accumulation, brain atrophy, and cognitive decline. Evidence from both focal and global cerebral ischemia animal models, as well as human studies, indicates that H2 exerts pleiotropic neuroprotective effects. A proposed mechanism involves the suppression of aging-related alterations in cellular proteins such as amyloid and tau. H2 administration was associated with improvements in cognitive and neurological deficits and with delayed onset of neurodegenerative changes. The review also compiles experimental and clinical data supporting the safety and efficacy of H2 use after cerebral ischemia, highlighting its potential as a novel agent for progressive post-ischemic dementia.

### Mechanism

H2 is proposed to suppress aging-related modifications of amyloid and tau proteins while reducing neuroinflammation and oxidative stress, thereby attenuating post-ischemic neurodegeneration in the hippocampal CA1 region.

## Bibliographic

- **Authors**: Pluta R, Januszewski S, Czuczwar SJ
- **Journal**: Int J Mol Sci
- **Year**: 2022 (2022-06-13)
- **PMID**: [35743035](https://pubmed.ncbi.nlm.nih.gov/35743035/)
- **DOI**: [10.3390/ijms23126591](https://doi.org/10.3390/ijms23126591)
- **PMC**: [PMC9224395](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224395/)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 35743035. https://h2-papers.org/en/papers/35743035
> **Source**: PubMed PMID [35743035](https://pubmed.ncbi.nlm.nih.gov/35743035/)