# Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells.
> 分子状水素が妊娠維持に与える影響：ミトコンドリア機能増強とT細胞免疫調節作用の観点から


## Abstract

This prospective observational study examined the relationship between endogenous hydrogen production and preterm birth (PTB). Exhaled H2 concentrations were significantly lower in pregnant women who experienced PTB, suggesting a potential role as a predictive biomarker. In vitro experiments using T cells from healthy donors demonstrated that H2 influenced cell differentiation, proliferation, and energy metabolism, acting as an immunomodulator through mitochondrial function enhancement. Correlations were identified between H2 levels and multiple maternal cytokines. In pregnant mice, H2 administration suppressed inflammatory responses and reduced PTB incidence associated with T-cell activation. Collectively, these findings indicate that maternal H2 production may support prolonged gestation via immunomodulatory pathways, and monitoring exhaled H2 could serve as a clinical indicator in PTB risk assessment.

### Mechanism

H2 enhances mitochondrial function in T cells, improving energy metabolism and suppressing inflammatory cytokine production, thereby exerting immunomodulatory effects that may reduce the risk of preterm birth.

## Bibliographic

- **Authors**: Aoki C, Imai K, Mizutani T, Sugiyama D, Miki R, Koya Y, et al.
- **Journal**: Life Sci
- **Year**: 2022 (2022-11-01)
- **PMID**: [36115583](https://pubmed.ncbi.nlm.nih.gov/36115583/)
- **DOI**: [10.1016/j.lfs.2022.120955](https://doi.org/10.1016/j.lfs.2022.120955)
- **Study type**: human observational study
- **Delivery route**: mixed routes
- **Effect reported**: positive

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 36115583. https://h2-papers.org/en/papers/36115583
> **Source**: PubMed PMID [36115583](https://pubmed.ncbi.nlm.nih.gov/36115583/)