# Effects of carbohydrate-electrolyte dissolved alkaline electrolyzed water on physiological responses during exercise under heat stress in physically active men.
> 熱ストレス下運動時における炭水化物・電解質含有アルカリ電解水摂取が生理応答に与える影響


## Abstract

A double-blinded crossover randomized controlled trial examined the physiological effects of consuming 1400 mL of carbohydrate-electrolyte (CE)-dissolved alkaline electrolyzed water (AEW; 0.3 ppm hydrogen, pH 4.1) versus CE-dissolved purified water (pH 3.8) during exercise in a hot environment (35°C, 50% relative humidity). Ten physically active men performed 30-minute treadmill running at 65% heart rate reserve followed by 10 × 7-second maximal sprint cycling, with blood sampling at multiple time points. Repeated sprint cycling performance and oxidative stress markers showed no significant differences between conditions. However, blood lactate accumulation during submaximal treadmill running was significantly lower in the AEW condition. These findings indicate that AEW with CE may partially support endurance capacity during submaximal heat-stress exercise, though high-intensity repeated sprint performance was unaffected.

### Mechanism

Ingestion of AEW containing 0.3 ppm dissolved hydrogen was associated with reduced blood lactate accumulation during submaximal running, suggesting a partial modulation of glycolytic metabolism under heat-stress conditions.

## Bibliographic

- **Authors**: Dobashi S, Kobayashi T, Tanaka Y, Shibayama Y, Koyama K
- **Journal**: Curr Res Physiol
- **Year**: 2022
- **PMID**: [36193515](https://pubmed.ncbi.nlm.nih.gov/36193515/)
- **DOI**: [10.1016/j.crphys.2022.09.007](https://doi.org/10.1016/j.crphys.2022.09.007)
- **PMC**: [PMC9525732](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525732/)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: mixed

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 36193515. https://h2-papers.org/en/papers/36193515
> **Source**: PubMed PMID [36193515](https://pubmed.ncbi.nlm.nih.gov/36193515/)