# Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with mental disorder.
> メタンフェタミン乱用者の精神障害に対する分子状水素介入と腸内マイクロバイオームへの影響


## Abstract

This study examined the relationship between gut microbial alterations and neuropsychiatric symptoms in individuals with methamphetamine (METH) dependence. Depression and anxiety were assessed using self-rating scales (SDS and SAS), while gut microbiota composition was profiled via 16S rRNA gene sequencing. METH users exhibited elevated depression and anxiety scores alongside reduced bacterial alpha diversity compared with age-matched healthy controls. Female METH users showed marked reductions in hydrogen-producing bacteria, including Bacteroides and Roseburia. Hydrogen intervention delivered via drinking hydrogen-rich water and gas inhalation significantly reduced neuropsychiatric symptom scores. Inhalation additionally produced measurable shifts in gut microbiota profiles. The findings indicate that endogenous hydrogen production by intestinal bacteria is diminished in METH abusers, and that exogenous hydrogen supplementation may partially restore both microbial balance and mental health indices.

### Mechanism

METH abuse reduces hydrogen-producing gut bacteria such as Bacteroides and Roseburia, lowering endogenous H2 from anaerobic metabolism. Exogenous hydrogen supplementation via inhalation or ingestion may compensate for this deficit, modulating gut microbiota composition and alleviating neuropsychiatric symptoms.

## Bibliographic

- **Authors**: Wang Y, Wang M, Xie B, Wen D, Li W, Zhou M, et al.
- **Journal**: Brain Res Bull
- **Year**: 2023
- **PMID**: [36516898](https://pubmed.ncbi.nlm.nih.gov/36516898/)
- **DOI**: [10.1016/j.brainresbull.2022.12.003](https://doi.org/10.1016/j.brainresbull.2022.12.003)
- **Study type**: human observational study
- **Delivery route**: mixed routes
- **Effect reported**: positive

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

---

> **Cite as**: H2 Papers — PMID 36516898. https://h2-papers.org/en/papers/36516898
> **Source**: PubMed PMID [36516898](https://pubmed.ncbi.nlm.nih.gov/36516898/)