# Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study.
> 最大有酸素速度での疲労困憊走行パフォーマンスに対する運動前水素水摂取の効果：無作為化二重盲検プラセボ対照クロスオーバー試験


## Abstract

This randomized, double-blind, placebo-controlled crossover study enrolled 24 trained male track and field runners (mean age 17.5 years, VO2max 55.0 ml·kg⁻¹·min⁻¹) to examine whether pre-exercise hydrogen-rich water (HRW) ingestion influences exhaustive running capacity. Participants consumed 1260 ml of HRW in four divided doses beginning 120 minutes before exercise. The running protocol included a warm-up, a transition phase, and a final phase at each individual's maximal aerobic speed until exhaustion. Compared with placebo, HRW produced no significant differences in time to exhaustion (217 vs. 227 s, p=0.20), post-exercise blood lactate (9.9 vs. 10.1 mmol·L⁻¹, p=0.42), maximal heart rate (186 vs. 186 beats·min⁻¹, p=0.80), or oxygen uptake (53.1 vs. 52.2 ml·kg⁻¹·min⁻¹, p=0.33). No candidate moderator variable correlated significantly with time to exhaustion. The findings indicate an absence of ergogenic benefit from acute pre-exercise HRW consumption in this population.

### Mechanism

No specific mechanistic pathway was investigated in this study; the ergogenic potential of HRW on aerobic running performance was assessed at the physiological outcome level without mechanistic analysis.

## Bibliographic

- **Authors**: Valenta M, Botek M, Krejčí J, McKune A, Sládečková B, Neuls F, et al.
- **Journal**: PLoS One
- **Year**: 2022
- **PMID**: [36538554](https://pubmed.ncbi.nlm.nih.gov/36538554/)
- **DOI**: [10.1371/journal.pone.0279307](https://doi.org/10.1371/journal.pone.0279307)
- **PMC**: [PMC9767360](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767360/)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: null

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 36538554. https://h2-papers.org/en/papers/36538554
> **Source**: PubMed PMID [36538554](https://pubmed.ncbi.nlm.nih.gov/36538554/)