# New Treatment for the Cognitive and Emotional Deficits Linked with Paclitaxel-Induced Peripheral Neuropathy in Mice.
> パクリタキセル誘発性末梢神経障害に伴う認知・情動障害に対する水素富化水の効果：マウスモデルによる検討


## Abstract

Using male mice administered paclitaxel (PTX) to model chemotherapy-induced peripheral neuropathy (PIPN), this study evaluated the effects of hydrogen-rich water (HRW) on pain and neuropsychiatric comorbidities. HRW given once or twice daily for 3–7 consecutive days reduced mechanical and thermal allodynia. Kv7 potassium channels and the Nrf2–heme oxygenase-1–NQO1 antioxidant pathway were implicated in these analgesic effects. HRW also suppressed memory impairment and anxiety- and depressive-like behaviors associated with PIPN. In the prefrontal cortex, HRW normalized elevated p-ERK1/2, p-Akt, and 4-hydroxynonenal levels while enhancing antioxidant enzyme activity. These findings suggest HRW may be a safe and effective candidate for addressing both the nociceptive and cognitive-emotional dimensions of PIPN.

### Mechanism

HRW exerts analgesic effects via Kv7 potassium channel modulation and activates the Nrf2–heme oxygenase-1–NQO1 pathway to reduce oxidative stress, thereby normalizing elevated p-ERK1/2, p-Akt, and 4-HNE in the prefrontal cortex.

## Bibliographic

- **Authors**: Martínez-Martel I, Bai X, Batallé G, Pol O
- **Journal**: Antioxidants (Basel)
- **Year**: 2022 (2022-12-01)
- **PMID**: [36552595](https://pubmed.ncbi.nlm.nih.gov/36552595/)
- **DOI**: [10.3390/antiox11122387](https://doi.org/10.3390/antiox11122387)
- **PMC**: [PMC9774817](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774817/)
- **Study type**: animal study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 36552595. https://h2-papers.org/en/papers/36552595
> **Source**: PubMed PMID [36552595](https://pubmed.ncbi.nlm.nih.gov/36552595/)