# Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.
> 脳疾患に対する分子状水素の神経保護作用：投与経路・疾患別効果・作用機序のレビュー


## Abstract

Oxidative stress and neuroinflammation are central to the pathophysiology of numerous neurodegenerative conditions and brain injuries. Following the pivotal 2007 discovery that molecular hydrogen scavenges peroxynitrite and hydroxyl radicals in ischemic stroke models, research into its antioxidant and anti-inflammatory properties has expanded considerably. This review examines the various routes by which hydrogen can be administered and evaluates its reported effects across a spectrum of brain disorders, including Alzheimer's disease, neonatal hypoxic-ischemic encephalopathy, depression, anxiety, traumatic brain injury, ischemic stroke, Parkinson's disease, and multiple sclerosis. The primary molecular mechanisms underlying hydrogen-mediated neuroprotection are also discussed. The authors highlight that identifying precise molecular targets, developing novel delivery strategies, and establishing optimal dosing regimens remain critical priorities for advancing future research and clinical application.

### Mechanism

Molecular hydrogen selectively neutralizes peroxynitrite and hydroxyl radicals, exerting neuroprotection through antioxidant and anti-inflammatory mechanisms that attenuate oxidative damage and neuroinflammatory cascades in the brain.

## Bibliographic

- **Authors**: Wu CY, Zou P, Feng S, Zhu L, Li F, Liu TT, et al.
- **Journal**: Mol Neurobiol
- **Year**: 2023
- **PMID**: [36567361](https://pubmed.ncbi.nlm.nih.gov/36567361/)
- **DOI**: [10.1007/s12035-022-03175-w](https://doi.org/10.1007/s12035-022-03175-w)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 36567361. https://h2-papers.org/en/papers/36567361
> **Source**: PubMed PMID [36567361](https://pubmed.ncbi.nlm.nih.gov/36567361/)