# Synthesis, characterization, and crystal structures of,'-bis-(2-di-alkyl-amino-phen-yl)thio-ureas.
> ジアルキルアミノフェニル基を有するチオウレア誘導体の合成・構造解析および結晶構造


## Abstract

Two thiourea derivatives, N,N'-bis[2-(dimethylamino)phenyl]thiourea and N,N'-bis[2-(diethylamino)phenyl]thiourea, were obtained by reacting 1,1'-thiocarbonyldiimidazole with two equivalents of the corresponding 2-amino-N,N-dialkylaniline. X-ray crystallographic analysis revealed intramolecular hydrogen bonding between the thiourea N-H groups and the dialkylaminophenyl nitrogen atoms. The remaining N-H bonds participate in intermolecular interactions with sulfur atoms of C=S groups in neighboring molecules within the crystal packing. Spectroscopic characterization by NMR and IR confirmed the structural assignments derived from crystallography.

## Bibliographic

- **Authors**: Lee KJ
- **Journal**: Acta Crystallogr E Crystallogr Commun
- **Year**: 2023 (2023-01-01)
- **PMID**: [36793414](https://pubmed.ncbi.nlm.nih.gov/36793414/)
- **DOI**: [10.1107/S2056989022012245](https://doi.org/10.1107/S2056989022012245)
- **PMC**: [PMC9912467](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912467/)
- **Study type**: other
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 36793414. https://h2-papers.org/en/papers/36793414
> **Source**: PubMed PMID [36793414](https://pubmed.ncbi.nlm.nih.gov/36793414/)