# Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity.
> 分子状水素の酸化還元メカニズムと健康長寿への寄与に関するレビュー


## Abstract

Age-related diseases pose a major challenge to global public health, with oxidative stress (OS) recognized as a central driver of their progression. OS arises from imbalances between pro- and anti-oxidant species, often linked to inherited or acquired dysfunction of redox-regulating enzymes, and leads to widespread cellular and molecular damage. Molecular hydrogen (H₂) has attracted growing interest as an antioxidant and anti-inflammatory agent, with evidence suggesting beneficial effects in conditions such as Alzheimer's disease, Parkinson's disease, cancer, and osteoporosis. Beyond direct radical scavenging, H₂ may support healthy aging by enriching beneficial intestinal microbiota, thereby enhancing endogenous intestinal hydrogen production and further reducing OS. This review examines the redox mechanisms through which H₂ exerts its effects, with particular emphasis on neurological conditions, and discusses how these mechanisms may contribute to extended healthful longevity.

### Mechanism

H₂ selectively neutralizes highly reactive oxygen species, including hydroxyl radicals and peroxynitrite, while also exerting anti-inflammatory effects and modulating gut microbiota to enhance endogenous hydrogen production and reduce systemic oxidative stress.

## Bibliographic

- **Authors**: Rahman MH, Jeong ES, You HS, Kim CS, Lee KJ
- **Journal**: Antioxidants (Basel)
- **Year**: 2023 (2023-04-24)
- **PMID**: [37237854](https://pubmed.ncbi.nlm.nih.gov/37237854/)
- **DOI**: [10.3390/antiox12050988](https://doi.org/10.3390/antiox12050988)
- **PMC**: [PMC10215238](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215238/)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

---

> **Cite as**: H2 Papers — PMID 37237854. https://h2-papers.org/en/papers/37237854
> **Source**: PubMed PMID [37237854](https://pubmed.ncbi.nlm.nih.gov/37237854/)