# The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis.
> 水素水摂取が臨床集団の血中脂質プロファイルに与える影響：系統的レビューおよびメタ解析


## Abstract

This systematic review and meta-analysis examined the relationship between hydrogen-rich water (HRW) intake and blood lipid parameters in clinical populations. A literature search following PRISMA guidelines was conducted across PubMed/Medline, Web of Science, and Scopus from inception through October 4, 2022. Seven studies met all eligibility criteria and were included in the pooled analysis. Results demonstrated statistically significant reductions in total cholesterol, low-density lipoprotein (LDL), and triglycerides following HRW consumption (p = 0.01), with small-to-moderate effect sizes (pooled SMD = −0.23, −0.22, and −0.38, respectively). These findings suggest that regular HRW intake may beneficially influence lipid and lipoprotein status in clinical populations, though additional well-powered trials are needed to confirm these observations.

### Mechanism

Molecular hydrogen's antioxidant and anti-inflammatory properties are proposed to modulate lipid metabolism, resulting in reductions in total cholesterol, LDL, and triglyceride concentrations in the bloodstream.

## Bibliographic

- **Authors**: Todorovic N, Fernández-Landa J, Santibañez A, Kura B, Stajer V, Korovljev D, et al.
- **Journal**: Pharmaceuticals (Basel)
- **Year**: 2023 (2023-01-18)
- **PMID**: [37259294](https://pubmed.ncbi.nlm.nih.gov/37259294/)
- **DOI**: [10.3390/ph16020142](https://doi.org/10.3390/ph16020142)
- **PMC**: [PMC9967957](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967957/)
- **Study type**: meta-analysis
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

---

> **Cite as**: H2 Papers — PMID 37259294. https://h2-papers.org/en/papers/37259294
> **Source**: PubMed PMID [37259294](https://pubmed.ncbi.nlm.nih.gov/37259294/)