# Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment.
> 局所組織微小環境の調節における分子状水素の標的としての肥満細胞の可能性


## Abstract

This review examines mast cells as a prospective cellular target through which molecular hydrogen (H₂) may modulate the local tissue microenvironment. H₂ appears to influence the processing of pro-inflammatory constituents within the mast cell secretome and their subsequent release into the extracellular matrix. Such modulation could meaningfully alter integrated-buffer metabolic capacity and reshape the immune landscape of local tissues. The authors discuss several candidate mechanisms underlying H₂ biological activity and consider their relevance to conditions including malignant neoplasms, diabetes mellitus, viral hepatitis, and mental or behavioral disorders. The review concludes that mast cell-centered pathways represent a promising avenue for translating H₂ research findings into clinical applications.

### Mechanism

H₂ is proposed to regulate the processing and extracellular matrix release of pro-inflammatory components within the mast cell secretome, thereby modulating the immune landscape and integrated-buffer metabolism of local tissue microenvironments.

## Bibliographic

- **Authors**: Atiakshin D, Kostin A, Volodkin A, Nazarova A, Shishkina V, Esaulenko D, et al.
- **Journal**: Pharmaceuticals (Basel)
- **Year**: 2023 (2023-05-30)
- **PMID**: [37375765](https://pubmed.ncbi.nlm.nih.gov/37375765/)
- **DOI**: [10.3390/ph16060817](https://doi.org/10.3390/ph16060817)
- **PMC**: [PMC10300919](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300919/)
- **Study type**: review
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 37375765. https://h2-papers.org/en/papers/37375765
> **Source**: PubMed PMID [37375765](https://pubmed.ncbi.nlm.nih.gov/37375765/)