# Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis.
> イミキモド誘発乾癬マウスモデルにおける水素富化浴の効果とその分子メカニズムの検討


## Abstract

Using an imiquimod-induced psoriasis mouse model, this study compared hydrogen-rich water baths with distilled water baths. Psoriasis severity index (PSI) scores were significantly lower in the hydrogen-rich bath group (p<0.01). Histological analysis revealed reduced abnormal keratosis, spinous-layer thickening, and Munro abscess formation. Throughout the disease course, peak and overall levels of IL-17, IL-23, TNF-α, CD3, and malondialdehyde (MDA) were significantly reduced in hydrogen-rich bath animals (p<0.05). Skin proliferating cell nuclear antigen (PCNA) expression was also attenuated. These findings indicate that hydrogen-rich bathing suppresses inflammatory cytokine activity and oxidative stress while curtailing aberrant epidermal proliferation in this psoriasis model.

### Mechanism

Hydrogen-rich bathing reduces pro-inflammatory cytokines (IL-17, IL-23, TNF-α) and oxidative stress markers (MDA), while suppressing PCNA-associated epidermal hyperproliferation, collectively attenuating psoriatic skin lesions.

## Bibliographic

- **Authors**: Zhang XQ, Yu P, Hong N, Liu FT, Shan Y, Wu Y, et al.
- **Journal**: Exp Dermatol
- **Year**: 2023
- **PMID**: [37391861](https://pubmed.ncbi.nlm.nih.gov/37391861/)
- **DOI**: [10.1111/exd.14872](https://doi.org/10.1111/exd.14872)
- **Study type**: animal study
- **Delivery route**: hydrogen bath
- **Effect reported**: positive

## Delivery context

Hydrogen bathing has reports of localized effects, but for systemic hydrogen intake the most efficient route is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen bathing has reports of localized effects, but for systemic hydrogen intake the most efficient route is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 37391861. https://h2-papers.org/en/papers/37391861
> **Source**: PubMed PMID [37391861](https://pubmed.ncbi.nlm.nih.gov/37391861/)