# EFFECT OF ACUTE HYDROGEN-RICH WATER INTAKE ON INTRAOCULAR PRESSURE IN HEALTHY SUBJECTS.
> 健康成人における水素水急速摂取が眼圧に及ぼす影響：無作為化二重盲検クロスオーバー試験


## Abstract

This prospective, randomized, double-blind crossover study enrolled 24 healthy volunteers (5 male, 19 female; ages 20–33) to examine how rapid consumption of 1260 ml of hydrogen-rich water (HRW), administered in three doses over 15 minutes, affects intraocular pressure (IOP) and central corneal thickness (CCT) relative to hydrogen-free water (placebo). Both conditions produced statistically significant IOP elevations from baseline. The peak rise reached 2.7 ± 2.0 mmHg at 25 minutes post-ingestion for HRW and 1.4 ± 2.0 mmHg at 35 minutes for placebo. Although mean IOP values did not differ significantly between groups, clinically meaningful individual IOP increases occurred more frequently after HRW (58%) than after placebo (25%). CCT remained unchanged throughout. These findings suggest that rapid HRW ingestion may carry a greater IOP-related risk than equivalent volumes of plain water, warranting further investigation in populations with glaucoma or ocular hypertension.

### Mechanism

Rapid ingestion of a large fluid volume may alter plasma osmolarity and increase aqueous humor production, elevating IOP; whether hydrogen itself contributes independently to this effect remains unclear from the current data.

## Bibliographic

- **Authors**: Najmanová E, Manethová H, Botek M, Pluháček F
- **Journal**: Cesk Slov Oftalmol
- **Year**: 2023
- **PMID**: [37567773](https://pubmed.ncbi.nlm.nih.gov/37567773/)
- **DOI**: [10.31348/2023/23](https://doi.org/10.31348/2023/23)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: adverse

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

---

> **Cite as**: H2 Papers — PMID 37567773. https://h2-papers.org/en/papers/37567773
> **Source**: PubMed PMID [37567773](https://pubmed.ncbi.nlm.nih.gov/37567773/)