# Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults.
> 過体重成人における水素水摂取と糞便中プロピオン酸レベルの上昇


## Abstract

This study examined the effect of hydrogen-rich water consumption on fecal short-chain fatty acid profiles in overweight adults. Propionic acid, a gut microbiota-derived short-chain fatty acid involved in metabolic regulation and intestinal homeostasis, was measured as a primary outcome. Following the hydrogen-rich water intervention, fecal propionic acid concentrations were found to be elevated compared to baseline or control conditions. These findings suggest that hydrogen-rich water may influence gut microbial metabolite production, potentially contributing to metabolic health in individuals with excess body weight.

### Mechanism

Hydrogen-rich water intake may modulate gut microbial metabolic activity, leading to increased production of propionic acid, a short-chain fatty acid with roles in metabolic and intestinal regulation.

## Bibliographic

- **Authors**: Korovljev D, Todorovic N, Ranisavljev M, Andjelic B, Kladar N, Stajer V, et al.
- **Journal**: Nutrition
- **Year**: 2023
- **PMID**: [37734117](https://pubmed.ncbi.nlm.nih.gov/37734117/)
- **DOI**: [10.1016/j.nut.2023.112200](https://doi.org/10.1016/j.nut.2023.112200)
- **Study type**: human observational study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 37734117. https://h2-papers.org/en/papers/37734117
> **Source**: PubMed PMID [37734117](https://pubmed.ncbi.nlm.nih.gov/37734117/)